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A comprehensive guide to 2C-B

This guide examines the history, content, effects, potential uses and potential risks of the drug 2C-B.

History of 2C-B

2C-B, or 2,5-dimethoxy-4-bromophenethylamine, is a synthetic psychedelic compound that falls within the class of phenylethylamine drugs.

It was first synthesised in 1974 by the famed chemist Alexander Shulgin, who is renowned for his extensive research on psychoactive compounds.

Shulgin described his findings on 2C-B, as well as numerous other compounds, in his book “PiHKAL” (Phenylethylamines I Have Known And Loved).

Initially marketed as an alternative to the popular party drug MDMA in the late 1970s and early 1980s, 2C-B was touted as having aphrodisiac properties and was sold under brand names like “Erox” and “Nexus”.

However, it wasn’t long before it caught the attention of regulators.

By the early 1990s, it was added to the list of Schedule I controlled substances in the U.S., making its production, sale, and possession illegal without a DEA licence.


2C-B is a psychoactive compound that structurally belongs to the 2C family of drugs, which include other substances like 2C-E, 2C-I, and 2C-T-7.

Chemically, it is derived from mescaline, a naturally occurring psychedelic found in certain cacti.

The compound is usually found in the form of a hydrochloride salt, which is a white or slightly pinkish crystalline powder.

Effects of 2C-B

The effects of 2C-B can vary based on dosage, individual physiology, and setting.

Typically, they can be felt within 20 to 90 minutes of ingestion and can last anywhere from 4 to 8 hours.

The effects of 2C-B are influenced by dosage, individual physiology, and setting.

After ingestion, the effects typically manifest between 20 and 90 minutes and can last from 4 to 8 hours.

Physically, users might experience stimulation which can give them a feeling of heightened energy or alertness.

It can also lead to pupil dilation, an increased heart rate and blood pressure, as well as enhanced tactile sensations.

Some might even feel mild nausea, especially during the initial stages.

On the psychoactive front, 2C-B can induce visual hallucinations characterised by intensified colours, patterns, and tracers.

Users often report an altered perception of time, an emotional intensification that can heighten feelings of empathy or interconnectedness, as well as euphoria or an enhanced mood.

Potential benefits and risks of 2C-B

There are a few positive aspects linked to 2C-B.

For instance, much like other psychedelics, there’s a burgeoning interest in its potential therapeutic applications, particularly in psychotherapy and the treatment of mood disorders.

Relative to other psychedelics, 2C-B is frequently perceived as producing a more “manageable” trip which is less intense or overpowering, especially when taken in moderate amounts.

Its shorter duration of effects compared to substances like LSD or psilocybin can be appealing to those hesitant about a prolonged experience.

At smaller doses, some find 2C-B to be a social enhancer, reminiscent of MDMA but without its pronounced empathogenic effects.

However, there are associated negatives to consider.

In numerous nations, 2C-B is classified as a controlled substance, rendering its possession, distribution, or manufacturing illegal.

As with all drugs, usage comes with inherent risks.

Taking large amounts or combining it with other drugs can lead to unfavourable reactions.

For some, it might amplify existing mental health issues or trigger feelings of anxiety or paranoia.

The experience isn’t consistent for everyone; a trip that’s enjoyable for one might be distressing for another.

Furthermore, there are reports of some users feeling unpleasant physical sensations, such as tension or discomfort, and some even mention potential hangovers the subsequent day.


2C-B is a unique psychedelic with a storied history and a range of effects that distinguish it from other hallucinogens.

While it offers certain benefits, potential users should be aware of the associated risks.

As with any psychoactive substance, it’s crucial to prioritize safety, understanding, and informed decision-making.


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